Related Experiment Videos
The structure of ribosome inactivating proteins
Jon D Robertus1, Arthur F Monzingo
1Institute of Cellular and Molecular Biology, Department of Chemistry and Biochemistry, 1 University Station A5300, University of Texas, Austin, TX 78712, USA. jrobertus@mail.utexas.edu
Mini Reviews in Medicinal Chemistry
|June 8, 2004
Abstract:
Ribosome Inactivating Proteins, RIPs, depurinate an invariant adenine from the 28S rRNA of eukaryotic ribosomes; they have evolved to near enzymatic perfection for this task. The N-glycosidase fold is conserved in plant and bacterial enzymes. RIPs can form complexes with cell surface recognition proteins that dramatically increase the cytotoxicity of the molecule.