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Updated: Aug 24, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
[Assessment of apolipoprotein E genotype in Parkinson disease patients with and without dementia]
Barbara Jasińska-Myga1, Grzegorz Opala, Stanisław Ochudło
1Katedry i Kliniki Neurologii Wieku Podeszłego, Slaskiej Akademii Medycznej w Katowicach. neurowp@infomed.slam.katowice.pl
Abstract:
The aim of our study was evaluation of the relationship between apolipoprotein E (APO E) genotype and the clinical parameters in Parkinson's disease (PD) with and without dementia. 104 PD patients were evaluated and within this group two subgroups were formed: 51 PD patients (25 males, 26 females; mean age: 70.4 +/- 6.03 years) with dementia and 53 (31 males, 22 females; mean age: 62.5 +/- 8.57 years) without dementia. The estimation of APO E genotype was executed by means of Polymerase Chain Reaction. The Unified Parkinson's Disease Rating Scale was used to quantify the severity of PD. Cognitive functions were assessed according to the Mini Mental State Examination. APO E genotype and allele frequencies did not differ between demented and nondemented parkinsonian patients.
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