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Updated: Jul 31, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
Published on: February 9, 2011
Epidemiology and prevention of skin and soft tissue infections
1Department of Dermatology, Geisinger Medical Center, Danville, Pennsylvania, USA.
Abstract:
Staphylococcus aureus and Streptococcus pyogenes remain the 2 major organisms responsible for most common skin and soft tissue infections. While methicillin-resistant S aureus (MRSA) typically is considered a hospital-acquired organism, outbreaks of community-acquired MRSA are being reported. Simple interventions can reduce the spread of this infection. Erysipelas is a streptococcal syndrome with high morbidity. The epidemiology has changed, with an increasing number of cases involving the lower extremities. Risk factors for erysipelas can be identified, which allow clinicians to target patients at high risk for recurrent disease. Although staphylococci and streptococci are the predominant cutaneous pathogens, enterococci and gram-negative organisms account for a significant proportion of skin infections.
Insights
Staphylococcus aureus and Streptococcus pyogenes cause common skin infections. Community-acquired methicillin-resistant S aureus (MRSA) outbreaks are increasing, but simple interventions can reduce spread.
Area of Science:
- Dermatology
- Infectious Diseases
- Microbiology
Background:
- Staphylococcus aureus and Streptococcus pyogenes are primary pathogens in skin and soft tissue infections.
- Methicillin-resistant Staphylococcus aureus (MRSA) is increasingly reported in community-acquired infections.
- Erysipelas, a streptococcal syndrome, shows changing epidemiology with more lower extremity cases.
Purpose of the Study:
- To review the epidemiology and risk factors of common skin pathogens.
- To highlight the changing landscape of Staphylococcus aureus and Streptococcus pyogenes infections.
- To inform clinical practice regarding the management and prevention of skin infections.
Main Methods:
- Literature review of Staphylococcus aureus and Streptococcus pyogenes infections.
- Analysis of epidemiological trends in skin and soft tissue infections.
- Identification of risk factors for erysipelas and recurrent infections.
Main Results:
- Staphylococcus aureus and Streptococcus pyogenes are leading causes of skin infections.
- Community-acquired MRSA outbreaks are a growing concern.
- Erysipelas cases are rising in lower extremities, with identifiable risk factors for recurrence.
- Enterococci and gram-negative organisms also contribute significantly to skin infections.
Conclusions:
- Understanding the evolving epidemiology of Staphylococcus aureus and Streptococcus pyogenes is crucial.
- Targeting high-risk patients can mitigate the impact of erysipelas.
- Simple interventions are effective in controlling the spread of MRSA.
- Comprehensive management of skin infections requires consideration of diverse bacterial pathogens.
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