Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Guiding neuronal growth cones using Ca2+ signals.

John Henley1, Mu-ming Poo

  • 1Division of Neurobiology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3200, USA.

Trends in Cell Biology
|June 9, 2004
PubMed
Summary

Neuronal growth cones navigate using molecular cues and calcium (Ca2+) signals. Modulating Ca2+ in growth cones may enhance central nervous system regeneration by overcoming inhibitory signals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SpatioTemporal Omics Consortium: a global effort for biological discovery across species, space and time.

Nature methods·2026
Same author

Towards China-initiated actions on AI safety and governance.

National science review·2026
Same author

Pinch restoration in post-stroke hemiplegia rehabilitation: A case report of motor task-synchronized precision repetitive transcranial magnetic stimulation.

Brain stimulation·2026
Same author

Exploring Long COVID diagnostic equity by sex, race and ethnicity, and insurance type.

Preventive medicine reports·2026
Same author

Cochlear nucleus spatial transcriptomes of normal and hearing loss mice reveal a critical role of Spp1 in bushy cells.

Cell research·2026
Same author

Evolutionary convergence and divergence of hippocampal cytoarchitecture between rodents and primates revealed by single-cell spatial transcriptomics.

National science review·2026

Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Background:

  • Axon pathfinding is crucial for nervous system development and regeneration.
  • Neuronal growth cones sense molecular guidance cues via surface receptors.
  • Cytoplasmic calcium (Ca2+) signals regulate growth cone motility and turning.

Purpose of the Study:

  • To investigate the role of Ca2+ signals in growth cone guidance.
  • To explore the potential of modulating Ca2+ for central nervous system regeneration.

Main Methods:

  • Analysis of Ca2+ signaling dynamics in growth cones.
  • Investigating the link between Ca2+ signals and cytoskeletal/membrane regulation.
  • Examining the effect of localized Ca2+ signals on growth cone steering.

Related Experiment Videos

Main Results:

  • Global Ca2+ signals control axon elongation by affecting cytoskeletal and membrane dynamics.
  • Localized Ca2+ signals induce asymmetric effector enzyme activation for growth cone steering.
  • Ca2+ signaling is a key regulator of growth cone motility.

Conclusions:

  • Ca2+ signals are essential for mediating neuronal guidance responses.
  • Targeting Ca2+ levels in growth cones presents a potential strategy to promote CNS regeneration.