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Updated: Aug 24, 2026

The Hypoxic Ischemic Encephalopathy Model of Perinatal Ischemia
Published on: November 19, 2008
The role of complement in neonatal hypoxic-ischemic cerebral injury
1Division of Neonatal Medicine and Neonatal Immunology Research Laboratory, Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY 40202-3830, USA. hal.lassiter@louisville.edu
Abstract:
Complement activation participates in tissue injury after temporary loss of blood flow (ischemia-reperfusion injury). Recently reported evidence indicates that complement activation is a pathologic mechanism of injury in the post-hypoxic-ischemic neonatal brain. Therefore, recently developed complement inhibitors may find a role in the amelioration of neonatal hypoxic-ischemic cerebral injury. Further research is needed to better define the role of complement in human neonatal cerebral injury and to determine the neuroprotective effect and safety of pharmacologic agents designed to inhibit complement.
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