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Eosinophilic cystitis after bladder instillation with dimethyl sulfoxide
Yoram Abramov1, Roger P Goldberg, Michael McGuire
1Division of Urogynecology and Reconstructive Pelvic Surgery, Evanston Continence Center, Evanston, Illinois 60201, USA.
Urology
|June 9, 2004
Summary
Eosinophilic cystitis, a rare bladder condition, can acutely flare after dimethyl sulfoxide (DMSO) bladder instillation. This case highlights the importance of considering DMSO
Area of Science:
- Urology
- Pathology
Background:
- Eosinophilic cystitis is a rare inflammatory bladder condition.
- Interstitial cystitis is a chronic condition causing bladder pain.
Observation:
- A 51-year-old woman experienced severe bladder pain, fever, and eosinophilia hours after dimethyl sulfoxide (DMSO) bladder instillation for presumed interstitial cystitis.
- Symptoms were unresponsive to standard pain and antibiotic treatments.
- Cystoscopy showed bladder wall erythema, exudate, and ureteral orifice edema.
Findings:
- Bladder biopsies confirmed massive eosinophilic infiltration, diagnosing eosinophilic cystitis.
- This represents the first reported case of acute eosinophilic cystitis flare post-DMSO instillation.
Implications:
- Clinicians should consider eosinophilic cystitis in patients with acute symptoms after DMSO instillation.
- This is particularly relevant for patients with multiple drug allergies.
- Awareness of this potential complication is crucial for urologists.