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Esophageal stenting with a self-expandable metallic device: a preliminary study
S Roy1, S S Baijal, T Ishiguchi
1Department of Radiology, Nagoya University School of Medicine, Japan.
Nagoya Journal of Medical Science
|March 1, 1992
Summary
Gianturco-Rosch Z stents show potential for use in the alimentary canal, maintaining patency in rabbit esophagi despite tissue reactions. Further research is needed to mitigate the inflammatory response for Z stent applications.
Area of Science:
- Gastroenterology
- Biomedical Engineering
- Surgical Innovation
Background:
- The Gianturco-Rosch Z stent is a novel device for gastrointestinal applications.
- Evaluating stent efficacy and tissue response in the alimentary canal is crucial for clinical translation.
Purpose of the Study:
- To investigate the feasibility and tissue response of the Gianturco-Rosch Z stent in the rabbit esophagus.
- To assess the patency and functional outcomes following Z stent implantation.
Main Methods:
- Single Gianturco-Rosch Z stents were implanted in the esophagus of four rabbits.
- Animals were monitored for periods ranging from 48 hours to 6 weeks post-implantation.
- Histopathological analysis was performed to evaluate tissue reactions.
Main Results:
- All implanted Z stents remained patent and in situ throughout the study period.
- A significant tissue reaction, including submucosal infiltration and mucosal erosion, was observed initially.
- Over time, mucosal regeneration and granulation tissue formation occurred, with patent stented segments.
- Feeding difficulties were transient, limited to the immediate post-procedure phase.
Conclusions:
- The Gianturco-Rosch Z stent is a viable option for the alimentary canal, as demonstrated by patency in the rabbit esophagus.
- Esophageal peristalsis does not appear to be a contraindication for Z stent use.
- Further studies are required to develop strategies for managing the observed tissue response to Z stents.