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Small unruptured aneurysm verification (SUAVe Study, Japan)--interim report
1Department of Neurosurgery, National Nagasaki Medical Center, Omura, Nagasaki, Japan. yonekura@nmc.hosp.go.jp
Neurologia Medico-Chirurgica
|June 10, 2004
Summary
The SUAVe study observed small unruptured intracranial aneurysms, finding an annual rupture rate of 0.8%. Key risk factors for rupture and enlargement include multiple aneurysms, female sex, age over 70, and specific locations.
Area of Science:
- Neurosurgery
- Neurology
- Epidemiology
Background:
- Small unruptured intracranial aneurysms require careful management to avoid rupture.
- Determining optimal surgical indications for these aneurysms is crucial.
Purpose of the Study:
- To observe the natural history of small unruptured intracranial aneurysms (under 5 mm).
- To identify factors influencing aneurysm rupture and enlargement.
- To inform surgical indications for small unruptured intracranial aneurysms.
Main Methods:
- Prospective observational study (SUAVe Study) across 13 Japanese national hospitals.
- Natural history observation of 380 small unruptured intracranial aneurysms in 329 patients.
- Follow-up duration averaged 13.8 months.
Main Results:
- Four aneurysms ruptured, yielding an annual rupture rate of 0.8% (95% CI 0.2-3%).
- Eighteen aneurysms enlarged, with seven requiring treatment for >2 mm growth.
- Risk factors for rupture/enlargement: multiple aneurysms, female sex, age >70, anterior communicating artery/basilar artery location.
Conclusions:
- The annual rupture rate for small unruptured intracranial aneurysms is approximately 0.8%.
- Multiple aneurysms may exhibit faster growth rates.
- Factors like multiplicity, sex, age, and location are critical for predicting rupture and enlargement risk.