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Cholesterol ester transfer protein in children on peritoneal dialysis

Yuriko Tanaka1, Takeshi Matsuyama, Kenji Ishikura

  • 1Department of Pediatrics, Fussa Hospital, Tokyo, Japan. yuriko@amy.hi-ho.ne.jp

Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis
|June 10, 2004
PubMed

Insights

Cholesterol ester transfer protein (CETP) activity is linked to lipid abnormalities in children undergoing peritoneal dialysis (PD). However, it does not explain the increased hyperlipidemia observed in younger patients with dyslipidemia.

Area of Science:

  • Biochemistry
  • Pediatric Nephrology
  • Lipid Metabolism

Background:

  • Dyslipidemia is a common complication in children on peritoneal dialysis (PD).
  • Cholesterol ester transfer protein (CETP) plays a role in lipoprotein metabolism and lipid transfer.
  • The specific contribution of CETP to dyslipidemia in pediatric PD patients remains unclear.

Purpose of the Study:

  • To investigate the association between CETP activity and mass with dyslipidemia in children on PD.
  • To determine if CETP activity or mass is responsible for more severe hyperlipidemia in younger PD patients.

Main Methods:

  • A cohort of 27 children on PD for over 6 months was studied.
  • Measurements included CETP activity, CETP mass, lipid profiles, apoprotein, and serum albumin.
  • Results were compared to a control group, with regression analyses used to examine relationships within the patient group.

Main Results:

  • Children on PD exhibited higher total cholesterol, triglycerides, LDL, VLDL, chylomicrons, and ApoB compared to controls.
  • While CETP activity did not differ significantly, CETP mass was lower in PD patients.
  • Specific CETP activity (activity/mass ratio) was significantly elevated in PD patients and correlated with atherogenic factors.

Conclusions:

  • Elevated specific CETP activity is associated with lipid abnormalities in pediatric PD patients.
  • CETP activity correlates with atherogenic factors but does not explain the severity of hyperlipidemia in younger children on PD.
Abstract

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