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Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
Surgical options in ischemic cardiomyopathy
Michele De Bonis1, Elisabetta Lapenna, Eleonora Ficarra
1Department of Cardiac Surgery, Vita e Salute University, San Raffaele Hospital, Milan, Italy. michele.debonis@hsr.it
Insights
Surgical interventions are evolving for ischemic cardiomyopathy, a growing condition. Optimized procedures like myocardial revascularization offer hope for patients with severe left ventricular dysfunction when heart transplantation isn't an option.
Area of Science:
- Cardiology
- Cardiovascular Surgery
- Heart Failure Research
Background:
- Ischemic dilated cardiomyopathy prevalence is rising in Western countries.
- Managing coronary artery disease with severe left ventricular dysfunction remains challenging.
- High mortality rates persist with medical therapy alone for this patient group.
Purpose of the Study:
- To review current and developing surgical interventions for ischemic cardiomyopathy.
- To highlight the need for optimized surgical strategies in advanced ischemic heart failure.
Main Methods:
- Review of conventional surgical procedures for ischemic cardiomyopathy.
- Discussion of myocardial revascularization, left ventricular restoration, mitral valve repair, device implantation, and atrial fibrillation ablation.
- Analysis of current use and ongoing development of these surgical techniques.
Main Results:
- Several surgical interventions are being refined for ischemic cardiomyopathy.
- Procedures include myocardial revascularization, ventricular restoration, and valve repair.
- Indications and outcomes for some procedures require further establishment.
Conclusions:
- Surgical management of ischemic cardiomyopathy is advancing.
- Optimized conventional procedures are crucial given limited heart transplant availability.
- Further research and data refinement will clarify optimal surgical strategies for advanced ischemic heart failure.
Abstract:
The prevalence of ischemic dilated cardiomyopathy in western countries is increasing despite improvements in prevention, diagnosis, and treatment of cardiovascular disease. The management of patients with coronary artery disease and severe left ventricular dysfunction continues to be challenging and the mortality rate with medical therapy alone in this setting remains very high. Since heart transplantation represents a realistic option just for a very small number of patients, in recent years a variety of classic surgical interventions have been improved or optimized to address the complex and multifactorial pathophysiology of the ischemic heart failure picture. Myocardial revascularization, left ventricular restoration, mitral valve repair, passive containment device implantation, and surgical ablation of atrial fibrillation represent some of the "conventional" procedures which are currently in use or under development for the surgical treatment of ischemic cardiomyopathy. For several of them, the exact indications and results are not yet established and significant changes and improvements should reasonably be waited over the next few years. As techniques are refined and more data become available, the optimum surgical strategy for patients with advanced ischemic heart failure is likely to become clearer and more effective.
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