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Ferric Chloride-induced Murine Thrombosis Models
Published on: September 5, 2016
Development of CoMFA, advance CoMFA and CoMSIA models in pyrroloquinazolines as thrombin receptor antagonist
Anshuman Dixit1, Sushil K Kashaw, Stuti Gaur
1Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India.
Bioorganic & Medicinal Chemistry
|June 10, 2004
Abstract:
3D QSAR studies namely CoMFA, advance CoMFA and CoMSIA have been carried out on a series of pyrroloquinazolines for their thrombin receptor antagonistic activity. The predicted activities by highly significant CoMFA (q2=0.66 and CoMSIA (q2=0.67) models were in good accordance with observed activities and the models may be useful for optimization of thrombin receptor antagonistic activity.
