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Four new andrographolide metabolites in human urine
Liang Cui1, Feng Qiu, Naili Wang
1Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang, P.R. China 110-016.
Chemical & Pharmaceutical Bulletin
|June 10, 2004
Abstract:
Andrographolide is one of principal components of a famous traditional Chinese herbal medicine Andrographis paniculate (BURM) NEES. Four new metabolites of andrographolide were isolated from human urine. All of them were characterized as sulfate and one of them also as a cysteine S-conjugate. The structures were determined to be andrographolide-3-O-sulfate (M-1), isoandrographolide-3-O-sulfate (M-2), 14-deoxyandrographolide-3-O-sulfate (M-3), 14-deoxy-12-(cysteine-S-yl)-andrographolide-3-O-sulfate (M-4), respectively, based on chemical evidence and spectroscopic analyses.