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Celiac disease and glycogenic acanthosis: a new association?

O D Suoglu1, H H Emiroglu, S Sokucu

  • 1Division of Paediatric Gastroenterology, Hepatology and Nutrition, Department of Pathology, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey.

Acta Paediatrica (Oslo, Norway : 1992)
|June 11, 2004
PubMed

Insights

This study reports a potential new association between celiac disease and glycogenic acanthosis in children. Further pediatric research is recommended to confirm this finding.

Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Pathology

Background:

  • Celiac disease is an autoimmune disorder triggered by gluten ingestion.
  • Iron deficiency anemia and failure to thrive are common symptoms in pediatric celiac disease.
  • Oesophageal manifestations of celiac disease are not well-documented.

Observation:

  • Two pediatric patients presented with anemia, failure to thrive, and positive antigliadin antibodies.
  • Endoscopy revealed grey-white plaques on the oesophageal mucosa.
  • Histopathology confirmed celiac disease and identified glycogenic acanthosis in the esophagus.

Findings:

  • This is the first reported instance of glycogenic acanthosis associated with celiac disease.
  • The co-occurrence suggests a potential link between the two conditions.
  • Glycogenic acanthosis may be an underdiagnosed esophageal finding in pediatric celiac disease.

Implications:

  • Investigating glycogenic acanthosis in pediatric celiac disease patients is warranted.
  • This association could lead to earlier diagnosis and improved management of celiac disease.
  • Further studies in larger pediatric cohorts are needed to validate this finding.
Abstract

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