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[Parasellar paraganglioma: a case report].

Céline Riopel1, Philippe Courville, Blandine Fabre

  • 1Service d'Anatomie Pathologique, Hôpital Charles Nicolle, CHU de Rouen, 1 rue de Germont, 76031 Rouen. Anatomie-Pathologie@chu-rouen.fr

Annales De Pathologie
|June 12, 2004
PubMed
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A rare neuroendocrine tumor, paraganglioma, was diagnosed in a 66-year-old man presenting with neurological symptoms. This case highlights a unique intrasphenoidal paracavernous mass, marking the first reported instance in French literature.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Oncology

Background:

  • Paragangliomas are rare neuroendocrine tumors originating from extra-adrenal chromaffin cells.
  • Intrasphenoidal paracavernous locations are exceptionally uncommon for these tumors.
  • Early diagnosis is crucial for effective management and improved patient outcomes.

Observation:

  • A 66-year-old male presented with diplopia, headache, and dizziness, indicative of neurological compromise.
  • Magnetic resonance imaging revealed a right intrasphenoidal paracavernous mass.
  • Endonasal biopsy of the lesion, appearing connected to the hypophyseal fossa, was performed.

Findings:

  • Histological examination showed a highly cellular tumor with variable architecture.
  • Tumor cells exhibited immunoreactivity for neuroendocrine markers.

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  • Spindle-shaped cells tested positive for S100 protein, consistent with paraganglioma.
  • Implications:

    • This case represents the first documented instance of intrasphenoidal paracavernous paraganglioma in the French literature.
    • The findings expand the known anatomical locations for paragangliomas.
    • Highlights the importance of considering rare tumors in the differential diagnosis of sellar and parasellar masses.