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Updated: Aug 23, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody (mAb) by Neutralizing TNF Using an In Vitro Bioanalytical Method
Published on: September 16, 2017
[Effect of the cannabinoid receptor ligand WIN-55,212-2 on the TNF-alpha production by human mononuclear cells]
E G Isachenko1, T I Vitkina, E V Berdyshev
1Laboratory of Biomedical Research, Vladivostok Department of the Far-Eastern Scientific Center of Breathing Physiology and Pathology, Institute of Medical Climatology and Restorative Therapy, Siberian Division, Russian Academy of Medical Sciences, Russia.
Abstract:
Synthetic cannabinoid WIN-55,212-2 produces a dose-dependent decrease on the TNF-alpha production by LPS-stimulated human mononuclear cells in vitro. The most pronounced inhibition of the TNF-alpha synthesis was observed for a drug concentration of 10 microM.
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