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Related Experiment Video

Updated: Jul 12, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Does maternal immunoglobulin E decrease with increasing order of live offspring? Investigation into maternal immune

W Karmaus¹, S H Arshad, A Sadeghnejad

¹Department of Epidemiology, Michigan State University, East Lansing, MI 48823, USA. karmaus@msu.edu

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology

|June 16, 2004

Summary

Having more children may reduce maternal IgE levels, potentially lowering allergy risks in subsequent offspring. This sibling effect suggests increased maternal immune tolerance with each live birth.

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Area of Science:

Immunology
Allergy Research
Reproductive Health

Background:

The sibling effect, where more siblings correlate with lower allergy risk, is a known phenomenon.
Understanding the mechanisms behind the sibling effect is crucial for preventing atopic diseases like asthma and eczema.

Purpose of the Study:

To test if increased live offspring number enhances maternal immune tolerance to allergens.
To investigate the association between maternal immunoglobulin E (IgE) levels and the number of live offspring.

Main Methods:

A cohort study of 1456 newborns on the Isle of Wight, UK.
Maternal and cord serum immunoglobulin E (IgE) levels were measured.
Linear and path analysis were used to examine the relationship between birth order and IgE.

Main Results:

Maternal IgE levels significantly decreased with a higher number of live offspring.
This reduction in maternal IgE was more pronounced in mothers with atopy.
Birth order directly impacted maternal IgE but not cord serum IgE.

Conclusions:

Maternal immune tolerance to allergens appears to increase with the number of live offspring.
Children born to mothers with a higher birth order may have a reduced risk of developing atopy.