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Network-level neuroplasticity in cortico-basal ganglia pathways
1Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, 45 Carleton Street, E25-618, Cambridge, MA 02139, USA. graybiel@mit.edu
Parkinsonism & Related Disorders
|June 16, 2004
Summary
The striatum, a key brain region, is crucial for adaptive plasticity in motor control circuits. This plasticity, while normal, can lead to maladaptive responses in basal ganglia diseases.
Area of Science:
- Neuroscience
- Neurobiology
- Systems Neuroscience
Background:
- The striatum is the largest input nucleus of the basal ganglia.
- It receives extensive input from the neocortex and thalamus.
- The striatum is central to the direct, indirect, and striosomal pathways.
Purpose of the Study:
- To propose the striatum as a primary site for adaptive plasticity within cortico-basal ganglia circuits.
- To explore the role of this plasticity in normal behavior and disease states.
Main Methods:
- Conceptual review and synthesis of existing literature on striatal function and plasticity.
- Analysis of the role of adaptive plasticity in cortico-basal ganglia circuits.
Main Results:
- The striatum acts as a significant locus for adaptive plasticity in the brain.
- This plasticity influences a wide array of behaviors under normal physiological conditions.
Conclusions:
- Striatal adaptive plasticity is fundamental to normal function.
- Dysregulation of this plasticity contributes to maladaptive responses observed in basal ganglia disorders.