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Early events in glutamate receptor trafficking
Wim Vandenberghe1, David S Bredt
1Department of Physiology, University of California at San Francisco, Genentech Hall N274, 600 16(th) Street, San Francisco, CA 94143, USA. wvan8672@itsa.ucsf.edu
Current Opinion in Cell Biology
|June 16, 2004
Abstract:
Glutamate receptors are the primary mediators of excitatory synaptic transmission in the mammalian central nervous system. Activity-dependent changes in the number of postsynaptic glutamate receptors underlie aspects of synaptic plasticity and provide a mechanism for information storage in the brain. Recent work shows that receptor exit from the endoplasmic reticulum represents a critical regulatory step in glutamate receptor trafficking to the neuronal cell surface.