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Pathogenesis of perinatal programming

Julie R Ingelfinger1

  • 1Pediatric Nephrology Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA. Jingelfinger@partners.org

Current Opinion in Nephrology and Hypertension
|June 17, 2004
PubMed

Insights

Perinatal programming, influenced by maternal health and nutrition, impacts later-life renal and cardiovascular disease risk. Early interventions can mitigate these long-term health outcomes.

Area of Science:

  • Perinatal programming
  • Developmental origins of health and disease (DOHaD)

Background:

  • Epidemiological studies link birth weight to cardiovascular disease.
  • The perinatal environment influences vasculogenesis and nephrogenesis.
  • Prenatal and postnatal growth impact future vascular, renal, and metabolic function.

Purpose of the Study:

  • To review recent findings on factors initiating perinatal programming.
  • To elucidate the effects of perinatal programming on later-life renal and cardiovascular disease.

Main Methods:

  • Review of epidemiological studies in humans.
  • Analysis of experimental models.
  • Synthesis of recent research reports.

Main Results:

  • Maternal nutrition and health affect nephrogenesis and renal function.
  • Compromised maternal nutrition can alter renal tubular transporters, impacting later renal function.
  • Hormonal systems influenced by maternal nutrition can lead to structural and functional renal changes.

Conclusions:

  • Research is clarifying perinatal programming mechanisms.
  • Educational programs promoting therapeutic interventions may reduce perinatal risks and long-term disease.
  • Early life interventions are crucial for mitigating long-term health consequences.
Abstract

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