Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement activation in neonatal infection.

M Peakman1, G Senaldi, G Liossis

  • 1King's College School of Medicine and Dentistry, Department of Immunology, London.

Archives of Disease in Childhood
|July 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world management of juvenile autoimmune liver disease.

United European gastroenterology journal·2018
Same author

Interferon-free therapy in hepatitis C virus mixed cryoglobulinaemia: a prospective, controlled, clinical and quality of life analysis.

Alimentary pharmacology & therapeutics·2018
Same author

Spectroscopic identification of r-process nucleosynthesis in a double neutron-star merger.

Nature·2017
Same author

Immunosuppressive drugs affect interferon (IFN)-γ and programmed cell death 1 (PD-1) kinetics in patients with newly diagnosed autoimmune hepatitis.

Clinical and experimental immunology·2017
Same author

Autoimmune hepatitis: From mechanisms to therapy.

Revista clinica espanola·2016
Same author

HBsAg plasma level kinetics: a new role for an old marker as a therapy response predictor in vertically infected children on combination therapy.

Journal of viral hepatitis·2014
Same journal

Protecting adolescent confidentiality in the digital age: a global call for adolescent-informed electronic health records.

Archives of disease in childhood·2026
Same journal

Diagnostic accuracy study assessing the ability of paediatric asthma scores to predict admission following initial emergency department bronchodilator therapy: a Clinical Asthma Scoring systems in Paediatric Emergency (CASPER) study.

Archives of disease in childhood·2026
Same journal

Artificial intelligence for child health: current capabilities and the next frontier.

Archives of disease in childhood·2026
Same journal

Troubled origins and lasting impact of the first insulin injection.

Archives of disease in childhood·2026
Same journal

Paediatric readiness assessment tools in emergency care: a scoping review.

Archives of disease in childhood·2026
Same journal

Building a paediatric workforce to deliver the NHS prevention agenda: time for paediatric public health medicine?

Archives of disease in childhood·2026
See all related articles

Complement activation products like Ba can help diagnose neonatal infections. High Ba levels indicate infection in newborns, offering a sensitive and specific early indicator.

Area of Science:

  • Neonatal Medicine
  • Immunology
  • Clinical Diagnostics

Background:

  • Neonatal infections pose significant diagnostic challenges.
  • Early and accurate diagnosis is crucial for effective treatment and improved outcomes.
  • Conventional diagnostic methods may have limitations in sensitivity and specificity.

Purpose of the Study:

  • To evaluate the diagnostic utility of complement activation products (C4d, Ba, C3d) in neonatal infections.
  • To compare these markers with conventional clinical, hematological, and C-reactive protein criteria.
  • To identify reliable early indicators of infection in newborns.

Main Methods:

  • Measurement of complement activation fragments (C4d, Ba, C3d) in 42 neonates with suspected infections.
  • Comparison with microbiological confirmation, clinical/hematological data, and C-reactive protein levels.

Related Experiment Videos

  • Inclusion of a control group of 14 neonates without suspected infection.

    • Main Results:

    • Elevated levels of C4d, Ba, and C3d were observed in neonates with confirmed infections compared to those with suspected infections and negative cultures.
    • Ba and C3d levels were significantly higher in infected neonates than in controls.
    • C-reactive protein and platelet count did not significantly differentiate between proven and suspected infections, though C-reactive protein was higher in suspected infections than controls.
    • High Ba concentrations demonstrated the highest sensitivity (47.1%) and specificity (92.0%) for predicting microbiologically proven infections.

    Conclusions:

    • Complement activation products, particularly Ba, show promise as early diagnostic indicators for neonatal infections.
    • Ba may serve as a valuable biomarker for identifying infection in the neonatal period.
    • Further research can explore the integration of complement activation markers into routine neonatal sepsis diagnostics.