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Perspectives on the nature of BCR-mediated survival signals
Susan Harless Smith1, Michael Reth
1Department of Molecular Immunology, Max-Planck Institute for Immunobiology, Stübeweg 51, AG Reth, D-79108 Freiburg, Germany.
Abstract:
In the June 11 issue of Cell, Kraus et al. (2004) show, through conditional mutagenesis, that mature B cells have a drastically reduced life span in the absence of normal B cell antigen receptor (BCR) surface expression or tonic signal transduction. These studies support a role for signal transduction downstream of the BCR, rather than continued surface expression per se for the maintenance and survival of mature B cells in the periphery. Further, these studies exclude transient INF(gamma)-induced activation as a prerequisite to apoptosis in receptor-less cells.
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