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Related Experiment Videos

'Black cornea' after long-term epinephrine use.

P K Kaiser1, R Pineda, D M Albert

  • 1Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|September 1, 1992
PubMed
Summary

A corneal lesion, initially mistaken for uveal prolapse, was diagnosed as adrenochrome deposition. This case highlights how misdiagnosis can lead to unnecessary eye surgery.

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Area of Science:

  • Ophthalmology
  • Pathology

Background:

  • A patient with a history of left antral carcinoma, treated with maxillectomy and radiation, developed phthisis and a corneal lesion.
  • The patient had a decade-long history of unilateral glaucoma treated with topical medications including epinephrine borate.

Observation:

  • A large, black, smooth, and homogeneous corneal lesion was observed.
  • The lesion was clinically suspected to be uveal prolapse covered by epithelium.

Findings:

  • Histopathology revealed an acellular substance consistent with corneal adrenochrome deposition.
  • The substance stained positive for melanin with Fontana Masson stain and bleached with potassium permanganate.

Implications:

  • Corneal adrenochrome deposition can mimic other ocular conditions, potentially leading to misdiagnosis.

Related Experiment Videos

  • Accurate diagnosis of adrenochrome deposition is crucial to avoid unnecessary surgical interventions such as anterior exenteration.