Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Time-domain cross-correlation baroreflex sensitivity: performance on the EUROBAVAR data set.

Berend E Westerhof1, Janneke Gisolf, Wim J Stok

  • 1TNO-TPD-Biomedical Instrumentation, Academic Medical Centre, University of Amsterdam, The Netherlands. westerhof@tpd.tno.nl

Journal of Hypertension
|June 18, 2004
PubMed
Summary

A new cross-correlation baroreflex sensitivity (xBRS) method accurately measures baroreflex sensitivity and delay. This validated technique offers improved data yield and reduced variability for clinical and experimental use.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

How to view the autonomic nervous system as physiologist, anatomist and pharmacologist?

The Journal of physiology·2026
Same author

Why The Polyvagal Theory Is Untenable: An international expert evaluation of the polyvagal theory and commentary upon Porges, S.W. (2025). Polyvagal theory: current status, clinical applications, and future directions. Clin. Neuropsychiatry, 22(3), 169-184.

Clinical neuropsychiatry·2026
Same author

Systolic BP Amplification: Systematic Review and Individual Participant Meta-Analysis.

Hypertension (Dallas, Tex. : 1979)·2025
Same author

Impaired autonomic cardiovascular control in people with HIV on long-term successful treatment.

AIDS (London, England)·2025
Same author

Case report: Extreme respiratory sinus arrhythmia in a non-athlete female student - a peculiar finding at the Physiology practicum.

Frontiers in neuroscience·2024
Same author

Baroreflex Sensitivity and Long-Term Dementia Risk in Older Adults.

Hypertension (Dallas, Tex. : 1979)·2024

Area of Science:

  • Cardiovascular Physiology
  • Autonomic Nervous System Function
  • Biomedical Signal Processing

Background:

  • Baroreflex sensitivity (BRS) is a crucial indicator of cardiovascular autonomic regulation.
  • Accurate computation of time-domain BRS from spontaneous variability is essential for clinical assessment.
  • Existing methods may have limitations in data yield and precision.

Purpose of the Study:

  • To evaluate a novel cross-correlation baroreflex sensitivity (xBRS) method for time-domain BRS computation.
  • To assess the performance of xBRS using the EUROBAVAR dataset, including diverse patient populations.
  • To compare xBRS-derived BRS values with established methods.

Main Methods:

  • The xBRS method was applied to 42 records from the EUROBAVAR dataset (lying and standing positions).

Related Experiment Videos

  • xBRS computes beat-to-beat systolic blood pressure and R-R interval correlation within a sliding 10s window with 0-5s delay.
  • Significant correlations (P=0.01) determined BRS slope and delay, with 1s computation intervals.

    • Main Results:

    • xBRS yielded BRS values comparable to EUROBAVAR averages (lying: 12.4 vs. 16.2 ms/mmHg; standing: 6.2 vs. 6.7 ms/mmHg).
    • The method provided more frequent results (20 values/min) with lower within-patient variance.
    • xBRS successfully processed data from patients with diabetes and heart transplant, and identified increased baroreflex delay in the standing position.

    Conclusions:

    • The xBRS method is a viable option for experimental and clinical BRS assessment.
    • Its ability to provide frequent, precise BRS values and measure baroreflex delay supports its utility.
    • xBRS demonstrates strong correlation with established BRS measures and robust performance in complex patient cases.