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CoMFA and CoMSIA 3D QSAR studies on pimarane cyclooxygenase-2 (COX-2) inhibitors
Kwang-Ok Lee1, Hyun-Ju Park, Young-Ho Kim
1College of Pharmacy, Seoul National University, Seoul 151-742, Korea.
Archives of Pharmacal Research
|June 19, 2004
Abstract:
Comparative molecular field analysis and comparative molecular similarity indices analysis were performed on twenty five analogues of pimarane COX-2 inhibitor to optimize their cyclooxygenase-2 (COX-2) selective anti-inflammatory activities.