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Dissociated glucocorticoid receptor ligands
Heike Schäcke1, Hartmut Rehwinkel
1Schering AG, Corporate Research, Müllerstrasse 178, 13342 Berlin, Germany. heike.schaecke@schering.de
Current Opinion in Investigational Drugs (London, England : 2000)
|June 19, 2004
Summary
Glucocorticoids are vital for treating inflammatory and autoimmune diseases but have side effects. Research aims to separate therapeutic benefits from adverse effects by targeting specific gene regulation pathways.
Area of Science:
- Pharmacology
- Molecular Biology
- Immunology
Background:
- Glucocorticoids are essential therapeutics for inflammatory and autoimmune conditions.
- Their clinical use is limited by significant undesirable side effects.
- Recent scientific advancements have elucidated distinct mechanisms for glucocorticoid receptor-mediated gene regulation.
Purpose of the Study:
- To explore the potential of dissociating therapeutic effects from side effects of glucocorticoids.
- To investigate ligands that selectively target specific glucocorticoid receptor pathways.
Main Methods:
- Discovery of differential mechanisms for positive and negative gene regulation by the glucocorticoid receptor.
- Development of novel ligands targeting specific pathways.
Main Results:
- Identification of distinct molecular pathways for therapeutic versus adverse effects.
- Progress in developing selective glucocorticoid receptor modulators.
Conclusions:
- It is potentially feasible to develop glucocorticoid-based therapies with improved safety profiles.
- Targeting specific gene regulation pathways offers a promising strategy for future drug development.