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Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
Published on: April 4, 2025
Aggregation and G-quadruplex DNA-binding study of 6a,12a-diazadibenzo-[a,g]fluorenylium derivative
Bernard Juskowiak1, Elzbieta Galezowska, Natalia Koczorowska
1Faculty of Chemistry, A. Mickiewicz University, 60-780 Poznan, Poland. juskowia@amu.edu.pl
Bioorganic & Medicinal Chemistry Letters
|June 19, 2004
Abstract:
The aggregation and DNA binding behavior of a new G-quadruplex selective ligand, 6a,12a-diazadibenzo-[a,g]fluorenylium derivative, was studied by UV-vis absorption and fluorescence spectroscopy. The formation of ligand aggregates with different spectral characteristics was observed at low and high concentration of NaCl, respectively. The ligand binds to G-quadruplex with much higher affinity than to single- and double-stranded DNA.
