Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Hematopoiesis in the elderly.

Leanne Berkahn¹, Armand Keating

¹Department of Molecular Medicine, University of Auckland, New Zealand.

Hematology (Amsterdam, Netherlands)

|June 19, 2004

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Myeloid/lymphoid neoplasms with eosinophilia and ZMYM2::FLT3 fusion: clinical, pathological and molecular clues to a cryptic diagnosis.

Pathology·2026

Same author

Intraperitoneal administration of NK-92 improves survival in xenografts of early and established ovarian cancer models.

PloS one·2026

Same author

IID 2025: Physical protein interaction data with detection types, co-purified protein sets, molecular docking, and immune cell networks.

Nucleic acids research·2025

Same author

A molecular systems architecture of the mesenchymal stromal cell microenvironment.

Stem cells (Dayton, Ohio)·2025

Same author

Reduced-intensity conditioning in LV-mediated gene therapy for Fabry disease targeting HSPCs.

Molecular therapy : the journal of the American Society of Gene Therapy·2025

Same author

Australia and New Zealand consensus statement on the cardiovascular management of patients with chronic lymphocytic leukaemia treated with Bruton's tyrosine kinase inhibitors.

Internal medicine journal·2025

Same journal

Raloxifene inhibits the proliferation of pediatric acute myeloid leukemia by targeting the ANP32B gene and regulating C-MYC expression.

Hematology (Amsterdam, Netherlands)·2026

Same journal

Characterization of a novel α-thalassemia deletion (Dongxing deletion; --<sup>DX</sup>) by CNV-seq in a Chinese female with Hb H disease: a case report.

Hematology (Amsterdam, Netherlands)·2026

Same journal

Real-world pegcetacoplan treatment of paroxysmal nocturnal hemoglobinuria patients with an unsatisfactory response to prior therapies.

Hematology (Amsterdam, Netherlands)·2026

Same journal

Distinct clinical, molecular, and treatment response profiles in primary and secondary myelofibrosis: a single-center retrospective study.

Hematology (Amsterdam, Netherlands)·2026

Same journal

Sirolimus-based treatment regimens for antinuclear antibody (ANA)-positive immune thrombocytopenia: a retrospective single-center cohort study.

Hematology (Amsterdam, Netherlands)·2026

Same journal

Relationship between major depressive disorder and venous thromboembolism: a five-ancestry genetic analysis.

Hematology (Amsterdam, Netherlands)·2026

See all related articles

Elderly patients can undergo high-dose therapy, including autologous stem cell transplantation. Age does not impede stem cell collection or recovery, showing comparable results to younger patients.

Area of Science:

Hematology
Gerontology
Immunology

Background:

Aging impacts the hematopoietic system, affecting lymphocyte and neutrophil function.
Unexplained anemia in the elderly is debated as physiological versus multifactorial.
Telomere shortening in aging hematopoietic cells raises concerns about stem cell function.

Purpose of the Study:

To investigate the impact of aging on hematopoietic stem cell function and transplantation outcomes.
To determine if age is a contraindication for high-dose therapy and autologous stem cell transplantation.
To evaluate the efficacy of stem cell collections from older patients.

Main Methods:

Review of existing human and animal studies on aging hematopoiesis.
Analysis of stem cell collection and transplantation data in elderly versus younger patients.

Related Experiment Videos

Assessment of neutrophil and platelet recovery times post-transplantation.

Main Results:

Evidence suggests anemia in the elderly is multifactorial, not physiological.
Stem cell collections from older patients are capable of restoring normal hematopoietic function.
Autologous stem cell transplantation shows comparable neutrophil and platelet recovery in older and younger patients.

Conclusions:

Age is not an obstacle for successful autologous stem cell transplantation.
Older patients are appropriate candidates for high-dose therapy and stem cell transplantation.
Hematopoietic stem cell function and recovery are preserved in elderly patients undergoing transplantation.