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A canine model for production of severe unilateral panacinar emphysema

Kimiaki Chino1, Cliff K Choong, P Diane Toeniskoetter

  • 1Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

Experimental Lung Research
|June 19, 2004
PubMed

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Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.