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Neonatal Proteus meningoencephalitis. Case report.

L Grahnquist¹, B Lundberg, K Tullus

¹Department of Paediatrics, St. Göran's Children's Hospital, Stockholm, Sweden.

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica

|August 1, 1992

Summary

Proteus mirabilis rarely causes neonatal meningitis, especially in Scandinavia. This case highlights the severe prognosis of early-onset Proteus meningitis, often leading to brain abscesses and death in infants.

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Area of Science:

Neonatal Medicine
Infectious Diseases
Microbiology

Background:

Proteus species are infrequent causes of neonatal meningitis.
Neonatal meningitis caused by Proteus has not been previously reported in Scandinavia.
Early-onset meningitis presents a significant challenge in neonatal intensive care.

Observation:

A preterm infant (36 weeks gestation) presented with decreased alertness.
The infant rapidly deteriorated, developing seizures and apnea within the first week of life.
The infant exhibited signs consistent with severe central nervous system involvement.

Findings:

The infant developed multiple brain abscesses.
The clinical course was rapidly progressive and fatal, despite medical intervention.

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Post-mortem examination confirmed severe brain damage.

Implications:

This case underscores the critical importance of considering Proteus as a potential pathogen in neonatal meningitis, even in previously unaffected regions.
Early-onset Proteus meningitis in neonates carries a high mortality and morbidity rate.
Prompt diagnosis and aggressive management are crucial, though the prognosis remains guarded for severe cases.