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Updated: Aug 23, 2026
A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
Published on: September 16, 2017
Standardized time to peak in ischemic and regular cerebral tissue measured with perfusion MR imaging
Christian Nasel1, Nicole Kronsteiner, Erwin Schindler
1Division of Neuroradiology, Department of Radiology, University of Vienna, Austria.
Background And Purpose:
Standardized time to peak (stdTTP) enables a quick quantification of time to peak measurements. An stdTTP /=7 seconds indicates critically perfused tissue. We verified this stdTTP in acute ischemia (within the first 6 hours after the onset of symptoms), when perfusion is critical, and after 24-72 hours.
Methods:
Combined diffusion-weighted imaging (DWI) and perfusion MR imaging was performed in 20 consecutive patients with acute cerebral ischemia. Distributions of stdTTP >/=7 and
Results:
About 80% of voxels in regions with ischemic injury showed an stdTTP >/=7 seconds. StdTTP of about 80% of voxels was /=7 seconds and resulting infarct (r(2)=0.86).
Conclusion:
StdTTP is reciprocal in regions with and without ischemic injury. An stdTTP >/=7 seconds (regular range) is strongly correlated with resulting infarct and reflects critical perfusion with a high probability of ischemic tissue injury in acute ischemia, whereas this is unlikely in regions with stdTTP
