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Prevalence of high C-reactive protein in persons with serum lipid concentrations within recommended values

Umed A Ajani1, Earl S Ford, Ali H Mokdad

  • 1Department of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA. uajani@cdc.gov

Clinical Chemistry
|June 19, 2004
PubMed

Insights

High C-reactive protein (CRP) affects millions of normolipidemic adults, indicating potential cardiovascular disease risk. Further research is needed to understand CRP

Area of Science:

  • Cardiology
  • Biomarkers
  • Public Health

Background:

  • C-reactive protein (CRP) is a key predictor of coronary heart disease (CHD).
  • Assessing CRP's role in cardiovascular disease (CVD) risk stratification is ongoing.
  • The prevalence of elevated CRP among normolipidemic individuals is not well-defined.

Purpose of the Study:

  • To determine the prevalence of high CRP levels in normolipidemic adults in the U.S.
  • To assess CRP prevalence in individuals without existing CHD or diabetes.
  • To analyze CRP prevalence based on body mass index (BMI).

Main Methods:

  • Analysis of National Health and Nutrition Examination Survey (NHANES) 1999-2000 data.
  • Calculation of high CRP (>3 mg/L) prevalence in normolipidemic adults.
  • Stratification of CRP prevalence by lipid fractions, CHD, diabetes, and BMI.

Main Results:

  • High CRP prevalence ranged from 28.8% to 35.3% in normolipidemic adults.
  • Excluding individuals with CHD, diabetes, or very high CRP (>10 mg/L) yielded 23.1-27.1% prevalence.
  • Elevated CRP prevalence increased with higher body mass index.

Conclusions:

  • Approximately 12 million normolipidemic U.S. adults had high CRP in 2000.
  • High CRP is prevalent even in individuals without traditional risk factors.
  • Further investigation into CRP's role in CVD risk assessment is warranted.
Abstract

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