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[Effect of quercetin on the acyclovir intestinal absorption]
Zhao-gang Yang1, Huan Meng, Xuan Zhang
1Department of Pharmaceutics, Peking University School of Pharmaceutical Sciences, Beijing 100083, China.
Summary
Quercetin enhances acyclovir intestinal absorption by inhibiting P-glycoprotein (P-gp) function. This study utilized everted gut sac and in vitro tests to confirm quercetin's effect on drug transport.
Area of Science:
- Pharmacology
- Drug Metabolism
- Gastrointestinal Physiology
Background:
- Acyclovir is an antiviral medication.
- Intestinal absorption is crucial for acyclovir's efficacy.
- P-glycoprotein (P-gp) is a transporter that can affect drug absorption.
Purpose of the Study:
- To investigate the impact of quercetin on acyclovir's intestinal absorption.
- To determine if quercetin affects P-glycoprotein activity.
Main Methods:
- Everted gut sac model to assess intestinal transport.
- In vitro intestinal absorption assays.
- High-Performance Liquid Chromatography (HPLC) for quantifying acyclovir transport.
Main Results:
- Quercetin significantly inhibited intestinal P-glycoprotein (P-gp) function.
- Acyclovir transport (mucosa to serosa) increased with quercetin exposure (0.3-1.0 fold).
- Quercetin decreased acyclovir transport (serosa to mucosa) in vitro.
Conclusions:
- Quercetin enhances acyclovir intestinal absorption.
- This enhancement is achieved by inhibiting P-glycoprotein function.