Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hippocampal function in cognition.

J David Sweatt1

  • 1Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030-3498, USA. jsweatt@bcm.tmc.edu

Psychopharmacology
|June 19, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthetic female gonadal hormones alter neurodevelopmental programming and behavior in F<sub>1</sub> offspring.

Hormones and behavior·2020
Same author

An Antisense Oligonucleotide Leads to Suppressed Transcription of Hdac2 and Long-Term Memory Enhancement.

Molecular therapy. Nucleic acids·2020
Same author

A myelin-related transcriptomic profile is shared by Pitt-Hopkins syndrome models and human autism spectrum disorder.

Nature neuroscience·2020
Same author

Broad domains of histone 3 lysine 4 trimethylation are associated with transcriptional activation in CA1 neurons of the hippocampus during memory formation.

Neurobiology of learning and memory·2019
Same author

Cognition-Enhancing Vagus Nerve Stimulation Alters the Epigenetic Landscape.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2019
Same author

Locus-Specific DNA Methylation Assays to Study Glutamate Receptor Regulation.

Methods in molecular biology (Clifton, N.J.)·2019
Same journal

Effects of repeated treatment with opioids that vary in mu opioid receptor efficacy on pain-depressed locomotor behavior in mice.

Psychopharmacology·2026
Same journal

Cannabidiol in the anterior insular cortex attenuates chronic neuropathic pain and comorbid anxiety- and depression-like behaviors: involvement of CB<sub>1</sub> and 5-HT<sub>1A</sub> receptor signaling.

Psychopharmacology·2026
Same journal

Fentanyl decreases arterial blood oxygen saturation more than furanylfentanyl in mice due to increased apnea.

Psychopharmacology·2026
Same journal

Suicide attempt risk among patients receiving methylphenidate: a retrospective cohort study.

Psychopharmacology·2026
Same journal

Investigating the impact of serotonergic psychedelic drugs, MDMA and ketamine on social cognition in psychiatric disorders: A scoping review.

Psychopharmacology·2026
Same journal

OPRD1 rs4654327 and Outcomes of Extended-Release Naltrexone in Alcohol Use Disorder: An Exploratory Prospective Pharmacogenetic Study.

Psychopharmacology·2026
See all related articles

The hippocampus is crucial for cognitive processing, integrating spatial and temporal information. Understanding its cellular basis may explain cognitive deficits in schizophrenia.

Area of Science:

  • Neuroscience
  • Cognitive Science

Background:

  • Cognitive disruption in schizophrenia necessitates understanding normal cognition's cellular and molecular basis.
  • The hippocampus is a key brain region implicated in cognitive functions.

Purpose of the Study:

  • To review emerging models for the cellular basis of cognitive processing in the hippocampus.
  • To explore the hippocampus's role in normal cognition and its relevance to schizophrenia.

Main Methods:

  • Review of in vivo recordings in behaving rodents.
  • Analysis of studies probing hippocampal function in cognition.

Main Results:

  • The hippocampus has a broader role in information processing than previously understood.
  • Evidence suggests hippocampal involvement in spatial processing, temporal sequencing, and object-environment relationships.

Related Experiment Videos

Conclusions:

  • The hippocampus integrates environmental signals for cohesive spatial and temporal perception.
  • Hippocampal dysfunction may underlie cognitive decline in schizophrenia, aligning with current models.