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Related Experiment Videos

Lidocaine kindling does not generate epilepsy.

V Voiculescu1, D Haţegan, E Manole

  • 1Institute of Neurology and Psychiatry, Bucharest, Romania.

Romanian Journal of Neurology and Psychiatry = Revue Roumaine De Neurologie Et Psychiatrie
|April 1, 1992
PubMed
Summary

Lidocaine injections in rats caused stiffness attacks, not epileptic seizures. This suggests that drug-induced brain changes, or plasticity, are broader than previously thought.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Neuroplasticity

Background:

  • Lidocaine is known to induce kindling, a process leading to epileptic seizures.
  • Previous studies reported typical epileptic seizures following lidocaine administration.

Purpose of the Study:

  • To investigate the effects of chronic lidocaine administration on Wistar rats.
  • To determine if lidocaine induces epileptic seizures or other neurological phenomena.
  • To compare lidocaine-induced effects with established models of central nervous system plasticity.

Main Methods:

  • Forty Wistar rats received subcutaneous lidocaine injections (90 mg/kg) five days weekly for 30-40 days.
  • Spinal cord hemisection at the thoracic level was performed to assess the origin of rigidity.
  • Electrocorticography and depth electrode recordings were used to monitor brain activity for paroxysmal discharges.

Main Results:

  • Stiffness attacks, characterized by hindlimb extension and immobility, occurred in 36 out of 40 rats.
  • These attacks lasted between 10 and 60 minutes.
  • Spinal cord hemisection abolished rigidity in the ipsilateral leg, indicating a spinal component.
  • No paroxysmal brain activity indicative of epileptic seizures was detected via cortical or temporal lobe recordings.

Conclusions:

  • Chronic lidocaine administration in rats induces stiffness attacks, distinct from typical epileptic seizures.
  • The findings challenge previous reports of lidocaine-kindled epileptic seizures.
  • Both epileptic kindling and lidocaine-induced stiffness demonstrate central nervous system plasticity, suggesting pharmacologically induced plasticity is a more general phenomenon.

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