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Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
Published on: December 18, 2012
[Postvaricella purpura fulminans]
L Alsina Manrique de Lara1, S Zambudio Sert, A Pizà Oliveras
1Sección de Urgencias, Servicio de Pediatría, Hospital Sant Joan de Déu-Clínic, Universitat de Barcelona, Paseo Sant Joan de Déu, 08950 Esplugues de Llobregat, Barcelona, Spain. cluaces@hsjdbcn.org
Abstract:
Purpura fulminans (PF) is an infrequent complication of varicella characterized by the progressive development of purpuric or painful ecchymotic lesions associated with biochemical alternations typical of consumption coagulopathy. Activation of coagulation is due to a marked and prolonged decrease in protein S, which is probably secondary to the formation of antiprotein S antibodies. The mechanism responsible for the synthesis of these autoantibodies is unknown. We present three cases of postvaricella PF and review the clinical and biochemical characteristics of this entity, as well as current diagnostic and therapeutic recommendations.
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