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Related Experiment Videos

Roughness response genes in osteoblasts.

P M Brett1, J Harle, V Salih

  • 1Department of Periodontology, Eastman Dental Institute, University College London, WC1X 8LD, UK. p.brett@eastman.ucl.ac.uk

Bone
|June 23, 2004
PubMed
Summary
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Titanium implant surface roughness significantly impacts bone cell gene expression. Modifying surface roughness offers a new strategy to enhance the biological activity and clinical success of dental and orthopedic implants.

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Orthopedic Research

Background:

  • Titanium (Ti) and its alloys are crucial for dental and orthopedic implants.
  • The influence of surface characteristics, particularly roughness, on tissue response in vivo remains unclear.
  • Understanding these effects is vital for improving implant efficacy.

Purpose of the Study:

  • To investigate the in vitro effects of different titanium surface roughness levels on bone cell responses.
  • To compare the cellular and gene expression profiles of smooth (SMO), sand-blasted/acid-etched (SLA), and plasma-sprayed (TPS) titanium surfaces.
  • To identify potential 'roughness' genes involved in bone cell response to titanium surfaces.

Main Methods:

  • Utilized three distinct titanium surface topographies: SMO, SLA (moderately rough), and TPS (highly rough).

Related Experiment Videos

  • Assessed surface chemistry using X-ray photoelectron spectroscopy and morphology via scanning electron microscopy.
  • Evaluated bone cell attachment, growth, and gene expression profiling using ATLAS gene arrays.

    • Main Results:

    • SLA surfaces showed transiently reduced cell attachment and delayed bone cell growth compared to SMO.
    • TPS surfaces promoted the greatest increase in bone cell numbers.
    • Significant differences in gene expression were observed, with TPS eliciting the most pronounced up- and down-regulation of genes.

    Conclusions:

    • Titanium surface roughness profoundly influences bone cell gene expression profiles.
    • Identified specific osteoblast genes responsive to surface roughness, termed 'roughness' genes.
    • Selective regulation of gene expression via surface roughness modification holds promise for enhancing implant biological activity and clinical performance.