Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

GSD: a genetic screen database.

Thorsten Henrich1, Mirana Ramialison, Erik Segerdell

  • 1European Molecular Biology Laboratory-Heidelberg, Meyerhofstrasse 1, D-69117 Heidelberg, Germany. henrich@embl.de

Mechanisms of Development
|June 24, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ExIR enables prioritizing driver and biomarker genes from omics data in a reference free manner.

iScience·2026
Same author

Application of spatial transcriptomics across organoids for a high-resolution, spatial whole-transcriptome benchmarking dataset.

iScience·2026
Same author

A panel of medaka isogenic lines suggests individual, seasonal, and sexual genetic variation of <i>bdnf</i> gene expression in the brain.

Frontiers in behavioral neuroscience·2026
Same author

Extrinsic polarity cues control lamination versus cluster-based organization in vertebrate retinal development.

iScience·2026
Same author

Hepatitis E virus replication is maintained in proliferative cells within the intestinal crypt.

Science advances·2026
Same author

Macrophages orchestrate antiviral defense and epithelial repair in a human iPSC-derived alveolar air-liquid interface.

JCI insight·2026
Same journal

Corrigendum to "Mechanisms of stress-related muscle atrophy in fish: An ex vivo approach"[Mech. Dev. (2018) 162-169].

Mechanisms of development·2020
Same journal

Conservation analysis of core cell cycle regulators and their transcriptional behavior during limb regeneration in Ambystoma mexicanum.

Mechanisms of development·2020
Same journal

Dm Ime4 depletion affects permeability barrier and Chic function in Drosophila spermatogenesis.

Mechanisms of development·2020
Same journal

Fetal programming by high-fat diet promoted the decreased of the prostate in adult Wistar albino rats.

Mechanisms of development·2020
Same journal

Pancreas development and the Polycomb group protein complexes.

Mechanisms of development·2020
Same journal

The Cdx transcription factors and retinoic acid play parallel roles in antero-posterior position of the pectoral fin field during gastrulation.

Mechanisms of development·2020
See all related articles

A new software package, GSD, facilitates gene function discovery by enabling the storage and integration of genetic screen data. This tool supports various screening types across different organisms, aiding researchers in analyzing developmental mutants and publishing results online.

Area of Science:

  • Genomics
  • Bioinformatics
  • Developmental Biology

Background:

  • Assigning gene function in post-genomic studies remains a significant challenge.
  • Large-scale genetic screens are crucial for functional genomics and understanding gene roles.
  • Existing data management tools may not adequately support diverse genetic screening methodologies.

Purpose of the Study:

  • To introduce GSD, a software package for storing and integrating genetic screen data.
  • To provide a flexible platform supporting various screening types and organisms.
  • To facilitate the analysis and dissemination of genetic screening results.

Main Methods:

  • Development of a relational database for genetic screen data storage.
  • Implementation of web interfaces for data accessibility and user interaction.

Related Experiment Videos

  • Creation of a phenotype classification ontology for medaka and zebrafish.
  • Integration of data management for screened embryos and genetic lines.
  • Inclusion of a query module for data retrieval and online publication.

    • Main Results:

    • GSD supports diverse genetic screens including mutagenesis, RNAi, morpholinos, and transgenesis.
    • The software allows detailed tracking of screened embryos, image submission, and phenotype description using an ontology.
    • A public fish phenotype classification ontology for medaka and zebrafish has been developed and released.
    • GSD enables the generation and categorization of genetic lines, integrating raw screening data.
    • A query module facilitates the publication of screen results online.

    Conclusions:

    • GSD offers a comprehensive solution for managing and integrating diverse genetic screening data.
    • The software enhances the systematic assignment of gene function by streamlining data analysis and accessibility.
    • The developed phenotype ontology and query module support efficient data sharing and discovery in functional genomics research.