Differential efficacy of clarithromycin in lung versus thigh infection models
Dana Maglio1, Blair Capitano, Mary Anne Banevicius
1Center for Anti-Infective Research and Development, Hartford Hospital, Conn., USA.
Background:
Differences in clarithromycin disposition and the resulting changes in bacterial density were studied using mouse lung and thigh infection models.
Methods:
Clarithromycin activity was evaluated against seven Streptococcus pneumoniae isolates with efflux-mediated resistance in both murine lung and thigh infection models. Intrapulmonary disposition of clarithromycin was also studied.
Results:
Consistent bacterial kill was observed in the lung model, whereas no drug effect was observed in the thigh model.
Conclusion:
These differences in bacterial density were supported by high concentrations observed in epithelial lining fluid as compared to serum.
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