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Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
12:55

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Published on: February 16, 2015

Molecular circuits of apoptosis regulation and cell division control: the survivin paradigm

Dario C Altieri1

  • 1Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01609, USA. dario.altieri@umassmed.edu

Journal of Cellular Biochemistry
|June 24, 2004
PubMed

Insights

The balance between cell division and cell death is vital for health. Survivin protein plays a key role in this process and is a target for new cancer therapies.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Cancer Research

Background:

  • Cell proliferation and cell death are critical for maintaining homeostasis.
  • Dysregulation of this balance can lead to disease, particularly cancer.
  • Survivin is a key molecule involved in both cell division and preventing cell death.

Purpose of the Study:

  • To elucidate the role of Survivin at the crossroads of cell proliferation and death.
  • To highlight Survivin's significance in cancer development and prognosis.
  • To explore Survivin's potential as a target for novel cancer therapies.

Main Methods:

  • Review of existing literature on Survivin's function.
  • Analysis of Survivin's role in cell division mechanisms.
  • Investigation of Survivin's involvement in apoptotic pathways.

Main Results:

  • Survivin protects against mitochondrial cell death.
  • Survivin regulates multiple aspects of cell division.
  • Survivin is frequently overexpressed in cancers, correlating with poor outcomes.

Conclusions:

  • The Survivin pathway is a critical regulator of cell fate.
  • Survivin's dual role makes it a promising target for cancer therapy.
  • Targeting Survivin offers a rational approach for developing new anti-cancer treatments.

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