Related Experiment Video
Updated: Jun 17, 2026
Non-Intubated Video-Assisted Thoracoscopic Surgery
Published on: May 26, 2023
[Comparative study on a short-term curative result between Nissen, Thal and Toupet fundoplications]
Zhicheng Xu1, Tingze Hu, Wenying Liu
1Department of Pediatric Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P. R. China.
Objective:
To compare the short-term curative results between Nissen, Thal and Toupet fundoplications in treatment of gastroesophageal reflux (GER) and to provide the basis for operative procedure.
Methods:
Thirty-three male Japan rabbits were randomly divided into six groups: group reflux (n = 7), transabdominal Heller's esophagomyotomy (TAHE); group Nissen (n = 7), TAHE and Nissen fundoplication; group Thal (n = 7), TAHE and Thal fundoplication; group Toupet (n = 7), TAHE and Toupet fundoplication; control group (n = 5), ventrotomy. The anti-reflux efficacy of fundoplication was evaluated by intraesophageal pH monitoring and MGV (maximal gastric volume sustained by lower esophageal sphincter) 4 weeks postoperatively.
Results:
1. The total number of reflux episodes and the reflux ratio (0.83 +/- 0.41, 2.20% +/- 1.12%) of group Nissen were significantly lower than those of group Thal (2.20 +/- 0.45, 4.32% +/- 0.82%) and group Toupet (1.80 +/- 0.45, 4.20% +/- 0.57%), respectively (P < 0.05). 2. MGV of group Nissen (233.00 +/- 9.44)ml was significantly larger than those of group Thal (203.40 +/- 11.13)ml and group Toupet (197.60 +/- 10.99)ml, respectively (P < 0.05). 3. There were no significant difference in total number of reflux episodes, reflux ratio and MGV between group Thal and group Toupet (P > 0.05).
Conclusion:
Nissen fundoplication was better than Thal and Toupet fundoplications, Thal and Toupet fundoplications are similar in short-term curative result.
