Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The hottest sentinel lymph node is not always the positive node.

E R Camp1, J C Cendan, R Feezor

  • 1Department of Surgery, University of Florida, College of Medicine, Gainesville, Florida 32610, USA.

The American Surgeon
|June 24, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A survey to determine the use and evaluation of simulation-based education within UK pre-registration diagnostic radiography education.

Radiography (London, England : 1995)·2025
Same author

Diagnostic radiography workforce expectations of learners against the 2023 HCPC standards of proficiency: Results of a UK Delphi study.

Radiography (London, England : 1995)·2024
Same author

Mapping the migrant diagnostic radiographers in the UK: A national survey.

Radiography (London, England : 1995)·2024
Same author

What do the revised UK standards of proficiency mean for diagnostic radiography training? A regional radiographer focus group study.

Radiography (London, England : 1995)·2023
Same author

Multiomics analysis of adaptation to repeated DNA damage in prostate cancer cells.

Epigenetics·2023
Same author

Radiographers' perceptions of first year diagnostic radiography students' performance following implementation of a simulation-based education model.

Radiography (London, England : 1995)·2023
Same journal

Perioperative Acute Myocardial Infarction in Non-Cardiac Operations: A National Analysis.

The American surgeon·2026
Same journal

Outcomes of Completion Cholecystectomy: Association With Patient Comorbidity in a National Database.

The American surgeon·2026
Same journal

Building the Conversation: Editorial Stewardship in Contemporary Surgical Publishing.

The American surgeon·2026
Same journal

Musculoskeletal Pain in Surgeons on Operating Days.

The American surgeon·2026
Same journal

Splenectomy During Cytoreductive Surgery: Marker of Surgical Burden or Independent Predictor of Morbidity?

The American surgeon·2026
Same journal

Predictors of a Long Hospital Stay After Abdominoperineal Resection of Rectal Cancer: Analysis of the National Cancer Database.

The American surgeon·2026
See all related articles

The hottest sentinel lymph node (SLN) is not always the one containing breast cancer. Researchers found that in 26% of cases, the tumor was in a less radioactive node, emphasizing the need to remove all radioactive nodes for accurate staging.

Area of Science:

  • Oncology
  • Surgical Pathology

Background:

  • Sentinel lymph node biopsy (SLNB) is crucial for breast cancer staging.
  • Current SLNB techniques often rely on identifying the most radioactive node using isotope counts.

Purpose of the Study:

  • To investigate whether the most radioactive sentinel lymph node (SLN) consistently harbors breast cancer metastasis.
  • To evaluate the accuracy of relying solely on the highest isotope count for SLN identification.

Main Methods:

  • A retrospective study of 247 breast cancer patients undergoing SLNB between April 1998 and April 2002.
  • Lymphatic mapping using radiocolloid injection, lymphoscintigraphy, and intraoperative gamma probe assessment.
  • Resection of all SLNs with radioactive counts ≥10% of the highest count, followed by detailed microscopic and immunohistochemical analysis.

Related Experiment Videos

Main Results:

  • Of 120 patients with multiple SLNs resected, 33 (28%) had tumor-bearing nodes.
  • In 25 (74%) of these cases, the tumor was in the most radioactive node.
  • However, in 8 (26%) cases, the metastatic node was a less radioactive SLN.

Conclusions:

  • The most radioactive node is not always the metastatic sentinel lymph node in breast cancer.
  • Relying solely on the highest radioactivity may lead to missed metastases.
  • Comprehensive analysis of all radioactive nodes is essential for accurate breast cancer staging and treatment planning.