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A flexible technology for modified release of drugs: multi layered tablets
1Department of Pharmaceutics, Principal K.M. Kundnani College of Pharmacy, Plot No. 47, R.G.Thadani Marg, Worliseafce, Mumbai-400018, India.
Summary
Modified release dosage forms using multi-layered matrices offer advantages over conventional ones. This advanced drug delivery system overcomes non-linear release issues, improving drug efficacy.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Modified release dosage forms offer advantages over conventional formulations.
- Hydrophilic polymers are key in matrix-type controlled delivery systems, often resulting in non-linear release profiles.
Purpose of the Study:
- To review the system design, constructions, and formulation parameters of multi-layered matrix modified release dosage forms.
- To highlight how multi-layered systems overcome the non-linearity inherent in diffusion-controlled matrix devices.
Main Methods:
- Review of existing literature on modified release dosage forms.
- Analysis of multi-layered matrix system design and formulation parameters.
- Discussion of the advantages and flexibility of this technology.
Main Results:
- Multi-layered matrix systems provide an additional release surface over time.
- This compensates for the decreasing release rate, leading to more predictable drug release.
- The technology offers significant flexibility for diverse pharmaceutical applications.
Conclusions:
- Multi-layered matrix systems represent an advancement in controlled drug delivery.
- This approach effectively addresses the non-linear release limitations of traditional matrix devices.
- Further exploration of system design and formulation is warranted for optimized drug delivery.