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Published on: February 13, 2016
A flexible technology for modified-release drugs: multiple-unit pellet system (MUPS)
Shajahan Abdul1, Anil V Chandewar, Sunil B Jaiswal
1P. Wadhwani College of Pharmacy, Yavatmal, Maharashtra, 445001, India.
Summary
This review updates research on compressing pellets into tablets, creating multiple-unit pellet systems (MUPS). It examines factors affecting pellet compaction for effective modified-release drug delivery.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
Background:
- Modified-release oral dosage forms offer therapeutic advantages over immediate-release options.
- Multiparticulate systems are commonly formulated into capsules or compressed tablets.
- Limited research exists on the compaction of pellets into tablets.
Purpose of the Study:
- To review the current state of research on pellet compaction into tablets.
- To discuss the phenomena and mechanisms involved in multiparticulate compaction.
- To identify material and process parameters influencing the tableting of multiparticulates.
Main Methods:
- Literature review of existing research on pellet preparation, coating, and compaction.
- Analysis of scientific articles discussing the tableting of multiparticulates.
- Synthesis of information on factors affecting multiple-unit pellet system (MUPS) formation.
Main Results:
- Pellet compaction into tablets (MUPS) is an emerging area with significant research gaps.
- Understanding compaction phenomena and mechanisms is crucial for successful MUPS development.
- Material properties and processing parameters critically influence the integrity and performance of MUPS.
Conclusions:
- Multiple-unit pellet systems (MUPS) represent a promising approach for modified-release formulations.
- Further research is needed to fully elucidate and optimize the pellet compaction process.
- Successful MUPS development requires careful consideration of both formulation and manufacturing variables.
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