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Subcellular Fractionation of Primary Chronic Lymphocytic Leukemia Cells to Monitor Nuclear/Cytoplasmic Protein Trafficking
Published on: October 23, 2019
Cutaneous findings in chronic lymphocytic leukaemia
K L Agnew1, R Ruchlemer, D Catovsky
1Department of Dermatology The Royal Marsden Hospital, London SW3 6JJ, U.K. karenagnew@lineone.net
The British Journal of Dermatology
|June 25, 2004
Summary
Dermatological conditions in Chronic Lymphocytic Leukaemia (CLL) patients often present atypically. This study identified various skin manifestations, including malignancies, in CLL cases, regardless of prior chemotherapy.
Area of Science:
- Oncology
- Dermatology
- Hematology
Background:
- Chronic lymphocytic leukaemia (CLL) is a B-cell malignancy with limited published dermatological data.
- A comprehensive survey of skin conditions in a large CLL cohort was previously unavailable.
Purpose of the Study:
- To document the range of dermatological conditions observed in a substantial group of CLL patients.
- To analyze the presentation and characteristics of these skin manifestations.
Main Methods:
- Retrospective analysis of clinical and photographic records from over 750 CLL patients.
- Classification, enumeration, and comparison of identified skin complications.
Main Results:
- 125 skin manifestations were identified in 40 CLL patients; 41 showed atypia, independent of immunosuppressive therapy.
- Cutaneous malignancies, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), frequently presented atypically.
- Other findings included infections (varicella zoster, herpes simplex, warts), leukaemia cutis, graft-versus-host disease, drug eruptions, and rare tumors.
Conclusions:
- CLL patients exhibit diverse dermatological conditions, often with atypical clinical and histological features.
- Atypia in these skin manifestations was observed irrespective of prior chemotherapy treatment.
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