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Updated: Aug 10, 2026

Mouse Models for Graft Arteriosclerosis
Published on: May 14, 2013
A method of preparing woven Dacron aortic grafts to prevent interstitial hemorrhage
Denton A. Cooley1, Alexander Romagnoli, John D. Milam
1Divisions of Surgery, Anesthesiology, and Pathology of the Texas Heart Institute and St. Luke's Episcopal Hospital, Houston, Texas.
Abstract:
Severe and even fatal hemorrhage may be caused by bleeding through the interstices of a fabric graft. Improved fabrication of grafts with appropriate porosity for the conditions encountered has provided better hemostasis. Yet in some situations, bleeding through the fabric still presents a problem. A method of preclotting with autologous platelet rich plasma (PRP) and autoclaving is described. Gross and microscopic studies along with clinical applications confirm the effectiveness of the technique.

