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08:51
A New Murine Model of Endovascular Aortic Aneurysm Repair
Published on: July 7, 2013
Infected aortic aneurysms: clinical outcome and risk factor analysis
Ron-Bin Hsu1, Robert J Chen, Shoei-Shen Wang
1Department of Surgery, National Taiwan University Hospital, National Taiwan University College of Medicine, Republic of China.
Journal of Vascular Surgery
|June 26, 2004
Summary
Primary infected aortic aneurysms have high mortality. Timely surgery and antibiotics improve outcomes, but advanced age, non-Salmonella infection, and delayed operation increase death risk.
Area of Science:
- Vascular Surgery
- Infectious Diseases
- Medical Outcomes Research
Background:
- Infected aortic aneurysms present significant treatment challenges and high mortality rates.
- Poor hospital survival is linked to severe infection, specific pathogens (Salmonella, Staphylococcus aureus), rupture, and suprarenal location.
- Understanding prognostic factors is crucial for managing these complex cases.
Purpose of the Study:
- To review the clinical outcomes of patients with primary infected aortic aneurysms.
- To identify clinical variables associated with prognosis in this patient cohort.
- To evaluate the effectiveness of surgical intervention and antibiotic therapy.
Main Methods:
- Retrospective chart review of 46 patients with primary infected aortic aneurysms.
- Univariate and multivariate logistic regression models employed for risk factor analysis.
- Analysis of patient data including infection type, aneurysm location, and treatment modality.
Main Results:
- Salmonella species were the most common pathogen (35/46 patients).
- In situ graft replacement had an 11% early mortality and 10% late prosthetic graft infection rate.
- Urgent operations had a 36% 90-day mortality compared to 0% for elective operations (P=.006).
- Advanced age, non-Salmonella infection, and lack of operation were independent predictors of aneurysm-related death.
Conclusions:
- In situ graft replacement with timely surgery and antibiotics offers excellent outcomes for primary infected aortic aneurysms, particularly with elective operations.
- Mortality remains high for patients requiring urgent surgical intervention.
- Advanced age, non-Salmonella infection, and عدم وجود operation are key determinants of mortality.
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