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[Minimal changes nephrotic syndrome associated to penicillamine treatment]
M A Basterrechea1, G de Arriba, F García-Martín
1Sección de Nefrología, Hospital Universitario de Guadalajara, Departamento de Medicina, Universidad de Alcalá.
Abstract:
We describe three patients with minimal change nephrotic syndrome associated with penicillamine treatment. Two patients had systemic sclerosis and one had rheumatoid arthritis. Cumulative dose of D-penicillamine was similar in all cases, and nephrotic syndrome appeared after 15-33 months of treatment. The drug was stopped and nephrotic syndrome disappeared in 2-4 months, suggesting a possible causal relationship between penicillamine and minimal change disease.