Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ultrasound-induced encapsulated microbubble phenomena.

Michiel Postema1, Annemieke van Wamel, Charles T Lancée

  • 1Department of Experimental Echocardiography, Thoraxcentre, Erasmus MC, Rotterdam, The Netherlands. m.postema@erasmusmc.nl

Ultrasound in Medicine & Biology
|June 29, 2004
PubMed
Summary

High-amplitude ultrasound causes encapsulated microbubbles to exhibit various behaviors, consistent with free gas bubble theories. Observed jetting phenomena suggest potential for targeted drug delivery, revolutionizing diagnostics and therapeutics.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Continuous shear wave measurements for dynamic cardiac stiffness evaluation in pigs.

Scientific reports·2026
Same author

A Clinical Perspective and Review on the Use of the Subharmonic Signal of Ultrasound Contrast Agents for Noninvasive Pressure Estimation.

Ultrasound in medicine & biology·2026
Same author

The accuracy of surface imaging in detecting secondary patient motion caused by pitch and roll corrections in pelvic radiotherapy.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2025
Same author

Real-time Imaging of Vascular Changes and Extravasation in the Chicken Chorioallantoic Membrane (CAM) Model Exposed to Ultrasound and Microbubbles.

Ultrasound in medicine & biology·2025
Same author

Diurnal variation of the distance between cranium and the third lumbar vertebra and its implications for craniospinal irradiation.

Physics and imaging in radiation oncology·2025
Same author

Ambient Pressure Sensitivity of Subharmonic Vibrating Single Microbubbles.

Ultrasound in medicine & biology·2025

Area of Science:

  • Acoustic physics
  • Biomedical engineering
  • Nanotechnology

Background:

  • Encapsulated microbubbles exhibit complex behaviors under high-amplitude ultrasound.
  • Existing theories for free gas bubbles provide a basis for understanding these phenomena.
  • Contrast agent microbubbles are widely used in medical imaging.

Purpose of the Study:

  • To explain microbubble phenomena (oscillation, fragmentation, jetting) under ultrasound.
  • To compare theoretical predictions with experimental observations of microbubbles.
  • To explore clinical applications of microbubble-ultrasound interactions.

Main Methods:

  • Applied established theories for free gas bubbles to encapsulated microbubbles.
  • Conducted high-speed optical observations of ultrasound-insonified contrast agent microbubbles.

Related Experiment Videos

  • Compared experimental results with theoretical models, including cavitation theory.

    • Main Results:

    • Observed phenomena like oscillation, fragmentation, and jetting in microbubbles.
    • Results largely align with free gas bubble theories and cavitation principles.
    • Documented jetting through microbubbles with pressures sufficient to penetrate human cells.

    Conclusions:

    • Microbubble behavior under ultrasound is largely predictable by free gas bubble dynamics.
    • Microbubble jetting presents a novel mechanism for targeted intracellular drug delivery (remote-controlled microsyringes).
    • Encapsulated microbubbles offer significant potential for both diagnostic and therapeutic clinical applications.