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Ambient Pressure Sensitivity of Subharmonic Vibrating Single Microbubbles.

Sander Spiekhout¹, Yuchen Wang¹, Tim Segers²

¹Biomedical Engineering, Department of Cardiology, Cardiovascular Institute, Erasmus Medical Center, Rotterdam, The Netherlands.

Ultrasound in Medicine & Biology

|March 5, 2025

Summary

This summary is machine-generated.

Ultrasound contrast agents

Keywords:

Ambient pressure sensitivity Blood pressure estimation Lipid-coated microbubbles Subharmonic-aided pressure estimation Ultrasound contrast agents

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Area of Science:

Biomedical Engineering
Acoustics
Materials Science

Background:

Ultrasound contrast agents exhibit pressure sensitivity.
Subharmonic signals from microbubbles are key for pressure sensing.
Non-invasive in vivo pressure measurement is a significant clinical need.

Purpose of the Study:

To investigate the pressure sensitivity of subharmonic oscillations in single microbubbles.
To elucidate the mechanisms behind microbubble response to ambient pressure variations.

Main Methods:

Experimental measurements of single microbubble subharmonic oscillation amplitude under varying pressures.
Numerical simulations to model microbubble behavior.
Utilized a monodisperse population of microbubbles near their resonance frequency.

Main Results:

Pressure changes induce minor bubble size alterations, affecting shell lipid packing density and stiffness.
A direct correlation was observed between ambient pressure and subharmonic oscillation amplitude.
Bubble resonance frequency shifts were identified as the primary driver of pressure-dependent subharmonic response.

Conclusions:

Microbubble subharmonic response is directly linked to ambient pressure via resonance frequency shifts.
Understanding this relationship is crucial for developing non-invasive pressure sensing technologies.
Findings support the use of ultrasound contrast agents for in vivo pressure monitoring.