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Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
Imaging and quantification of calcified corneal lesions with optical coherence tomography
Christopher Wirbelauer1, Duy Thoai Pham
1Klinik für Augenheilkunde, Vivantes Klinikum Neukölln, Rudower Str. 48, D-12351 Berlin, Germany. knk.augen@vivantes.de
Purpose:
The purpose of this study was to image and quantify calcified corneal lesions with optical coherence tomography (OCT) and to evaluate this diagnostic method to assess this corneal disease.
Methods:
In a clinical study 15 eyes of 14 patients with calcified corneal lesions in the anterior portions of the cornea were assessed with slit-lamp biomicroscopy and slit-lamp-adapted OCT. The qualitative and quantitative optical changes were compared with the clinical findings.
Results:
In corneal OCT all calcified lesions revealed marked hyperreflective changes that correlated well with macroscopic findings. Dense calcified lesions resulted in partial or complete shadowing of the posterior corneal structures. The thickness values for the hyperreflective calcified lesions ranged from 27 to 344 microm.
Conclusion:
Noncontact slit-lamp-adapted OCT may be of value in assessing calcified corneal lesions. Corneal OCT could also be used to precisely measure the depth of these corneal processes and evaluate treatment modalities.
